7-Day Miami to Florida Keys Road Trip

Your 7-Day RV Adventure from Miami to Key West

If you’ve been dreaming of white-sand beaches, endless sunshine, and palm-fringed roads, this Florida Keys road trip is the adventure for you.
Island-hop from Miami to Key West with 42 bridges beneath your wheels, turquoise waters on either side, and a salty breeze that smells like freedom. Whether you’re in a rental RV or your own camper, this itinerary is built for ease, spontaneity, and unforgettable moments.

Route

Miami ➤ Key Largo ➤ Marathon ➤ Key West ➤ Miami

Distance

329 miles

Trip Duration

7 days

Highlights

South Pointe Pier, Molasses Reef, Old Seven Mile Bridge, Key West Lighthouse, Mallory Square

Best Time to Visit

November to May

Tolls

Some toll roads and bridges apply along the route.


Stop 1 – Miami

We recommend 2 days

Your Miami to Florida Keys road trip begins in the heart of South Florida. As the starting point for this iconic island drive, Miami blends beaches, Art Deco architecture, and Latin culture into the perfect launchpad before heading south on the Overseas Highway. Whether you’re flying in or picking up your RV rental in Miami, spend time at South Beach, explore Wynwood’s murals, or wander Little Havana before trading skyline views for turquoise waters and palm-lined bridges.

Palm trees silhouetted against the sunrise over a calm lagoon in Miami, Florida.
Outdoor cafés and palm-lined Mediterranean buildings along Española Way in Miami Beach, Florida
Rows of colorful umbrellas hanging above Giralda Plaza in Coral Gables, Miami.
Colorful mural in Wynwood, Miami, reading “Greetings from Miami,” surrounded by vibrant graffiti art.
Display of fresh shrimp, oysters, crab, and shellfish on ice at a seafood market in Miami.

Tropical city skyline

Landscape

South Beach sunset

Highlight

Urban beach kickoff

Experience

Best for

  • Trip kickoff
  • Beach lovers
  • Art Deco fans

Things to do

  • South Beach walk
  • Art Deco District
  • Wynwood murals


Stop 2 – Key Largo

We recommend 1 day

The gateway to the Keys, Key Largo eases you into island life with laid-back charm. This stretch of your Florida Keys road trip itinerary is all about diving in—literally. Snorkel the coral reefs at John Pennekamp Coral Reef State Park or take a glass-bottom boat to glimpse a world beneath the waves. If you’re on an RV Florida Keys trip, nearby camping spots offer stunning sunrise views.

Aerial view over island covered by trees and houses.
Colorful coral reef teeming with tropical fish in the clear blue waters off Key Largo, Florida Keys.
Bartender mixing tropical drinks for two women at a rustic tiki bar on a sandy beach under a clear blue sky in the Florida Keys.
Small boat gliding across turquoise waters above coral reefs near Key Largo in the Florida Keys.

Coral reef waters

Landscape

John Pennekamp Reef

Highlight

Snorkeling and diving

Experience

Best for

  • Snorkel beginners
  • Reef exploration
  • Water activities

Things to do

  • John Pennekamp Park
  • Glass-bottom boat tour
  • Kayak mangroves


Stop 3 – Marathon

We recommend: 1 day

Situated in the middle of the Keys, Marathon is a perfect mid-point to slow things down. This is where your Florida Keys road trip turns scenic. Cross the Old Seven Mile Bridge for an unforgettable drive and stop by Pigeon Key to step back into Keys history. If you’re on the lookout for Key West camping ideas, Marathon has peaceful alternatives with ocean views.

Aerial view over an island showing the beach and multiple houses.
Sea turtle swimming in clear blue water at a rescue and rehabilitation center in the Florida Keys.
Aerial view of the Seven Mile Bridge stretching across turquoise waters in Marathon, Florida Keys.
Dense red mangroves reflected in calm green water in a coastal forest of the Florida Keys.
Wooden tables under thatched umbrellas overlooking turquoise water and anchored boats in the Florida Keys.

Island chain views

Landscape

Seven Mile Bridge

Highlight

Laid-back island stop

Experience

Best for

  • Scenic bridge drive
  • Family-friendly stops
  • Marine encounters

Things to do

  • Seven Mile Bridge
  • Sombrero Beach
  • Turtle Hospital visit


Stop 4 – Key West

We recommend: 2 days

Key West is the final stop on your Miami to Florida Keys road trip, where pastel houses, roaming chickens, and sunset gatherings at Mallory Square set the tone for a slower island pace. As the southernmost point of the Overseas Highway, it’s the perfect place to unwind before heading back north. If you’re traveling by RV, nearby state parks offer scenic camping spots just outside town—our guide to RV camping in the Florida Keys explains where to stay and what to expect.

Sailboat gliding past palm trees at sunset in Key West, Florida Keys.
Yachts and smaller boats parked in a small harbour, surrounded by multiple buildings.
Bright green and purple tropical bird perched on a wooden rail among lush palms in Key West.
Overhead view of the Seven Mile Bridge stretching across turquoise water in the Florida Keys.
Key lime dessert squares topped with powdered sugar and lime wedges on a wooden board.

Southernmost island city

Landscape

Mallory Square sunset

Highlight

Laid-back island stop

Experience

Best for

  • Sunset seekers
  • Nightlife lovers
  • Historic charm

Things to do

  • Duval Street stroll
  • Southernmost Point
  • Sunset celebration


Return to Miami

We recommend: 1 day

As your Miami to Florida Keys road trip comes full circle, spend one final day in Miami soaking up the city before departure. Revisit South Beach, catch a last sunset at South Pointe Park, and ease back into city life after driving the Overseas Highway. If you’re returning an RV rental in Miami, this is the perfect time to refuel and reset before wrapping up your Florida Keys road trip itinerary.

Aerial view over a city showing a harbour, the sea and skyscapers in the back.
Palm trees sway against the glowing Miami skyline at sunset, marking the perfect starting or ending point for a Florida East Coast road trip.

Tips for Your Florida Keys Road Trip

Whether it’s your first RV trip or you’re a seasoned road-tripper, a little prep goes a long way. These tips will help you start your Florida Keys adventure with everything in place—minus the stress.

  • Book campsites early. Florida State Parks fill up fast, especially in winter. You can reserve up to 11 months in advance on ReserveAmerica.
  • Pack for the heat. Reef-safe sunscreen, UV-protective clothing, and breathable layers are must-haves. A portable fan for your RV doesn’t hurt either.
  • Prep your RV gear. Make sure you’ve got leveling blocks, a water pressure regulator, electrical adapters, and bug spray. For a full list of what to bring, check out our RV camping packing list.

Once the wheels are rolling, the Keys unfold at their own pace. Here are a few road-savvy reminders to help you drive smoother, save money, and make the most of the journey.

  • Expect tolls. The Florida Turnpike and Homestead Extension are tolled. A SunPass gets you the best rates. You can estimate your trip cost with the toll calculator.
  • Fuel up when you can. Gas gets pricier the further you go into the Keys. Homestead and Key Largo usually offer the best prices.
  • Mind the highway rhythm. US-1 (Overseas Highway) can get congested. Mornings are quieter—great for scenic stops with fewer crowds.

You’ve made it to the tropics—now it’s time to settle in. From fees to parking to doing right by the reef, these tips will help you camp comfortably and respectfully.

  • Expect fees at state parks. Most charge $4–$8 per vehicle for day use. RV campsites range from $20–$42 per night plus a $7 utility fee. For details, see the fee schedule.
  • Parking in Key West can be tricky for RVs. Look for outer lots—downtown options often have size restrictions and $4+/hr rates.
  • Leave No Trace. Stick to trails, pack out your trash, and use reef-safe sunscreen to help protect local ecosystems and coral reefs.


Colorful lifeguard tower on Miami Beach, one of the best family vacation spots in Florida for sun and sand.

Start Your Miami to Florida Keys Road Trip

Hit the road with one of the largest RV fleets in the world. Whether you’re after a camper van, compact RV, or full-sized motorhome, your perfect ride is waiting in Miami—ready to take you all the way to Key West.

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