7-Day Miami to Florida Keys Road Trip
Your 7-Day RV Adventure from Miami to Key West
If you’ve been dreaming of white-sand beaches, endless sunshine, and palm-fringed roads, this Florida Keys road trip is the adventure for you.
Island-hop from Miami to Key West with 42 bridges beneath your wheels, turquoise waters on either side, and a salty breeze that smells like freedom. Whether you’re in a rental RV or your own camper, this itinerary is built for ease, spontaneity, and unforgettable moments.
Route
Miami ➤ Key Largo ➤ Marathon ➤ Key West ➤ Miami
Distance
329 miles
Trip Duration
7 days
Highlights
South Pointe Pier, Molasses Reef, Old Seven Mile Bridge, Key West Lighthouse, Mallory Square
Best Time to Visit
November to May
Tolls
Some toll roads and bridges apply along the route.
Stop 1 – Miami
We recommend 2 days
Your Miami to Florida Keys road trip begins in the heart of South Florida. As the starting point for this iconic island drive, Miami blends beaches, Art Deco architecture, and Latin culture into the perfect launchpad before heading south on the Overseas Highway. Whether you’re flying in or picking up your RV rental in Miami, spend time at South Beach, explore Wynwood’s murals, or wander Little Havana before trading skyline views for turquoise waters and palm-lined bridges.
Best for
- Trip kickoff
- Beach lovers
- Art Deco fans
Things to do
- South Beach walk
- Art Deco District
- Wynwood murals
Stop 2 – Key Largo
We recommend 1 day
The gateway to the Keys, Key Largo eases you into island life with laid-back charm. This stretch of your Florida Keys road trip itinerary is all about diving in—literally. Snorkel the coral reefs at John Pennekamp Coral Reef State Park or take a glass-bottom boat to glimpse a world beneath the waves. If you’re on an RV Florida Keys trip, nearby camping spots offer stunning sunrise views.
Best for
- Snorkel beginners
- Reef exploration
- Water activities
Things to do
- John Pennekamp Park
- Glass-bottom boat tour
- Kayak mangroves
Stop 3 – Marathon
We recommend: 1 day
Situated in the middle of the Keys, Marathon is a perfect mid-point to slow things down. This is where your Florida Keys road trip turns scenic. Cross the Old Seven Mile Bridge for an unforgettable drive and stop by Pigeon Key to step back into Keys history. If you’re on the lookout for Key West camping ideas, Marathon has peaceful alternatives with ocean views.
Best for
- Scenic bridge drive
- Family-friendly stops
- Marine encounters
Things to do
- Seven Mile Bridge
- Sombrero Beach
- Turtle Hospital visit
Stop 4 – Key West
We recommend: 2 days
Key West is the final stop on your Miami to Florida Keys road trip, where pastel houses, roaming chickens, and sunset gatherings at Mallory Square set the tone for a slower island pace. As the southernmost point of the Overseas Highway, it’s the perfect place to unwind before heading back north. If you’re traveling by RV, nearby state parks offer scenic camping spots just outside town—our guide to RV camping in the Florida Keys explains where to stay and what to expect.
Best for
- Sunset seekers
- Nightlife lovers
- Historic charm
Things to do
- Duval Street stroll
- Southernmost Point
- Sunset celebration
Return to Miami
We recommend: 1 day
As your Miami to Florida Keys road trip comes full circle, spend one final day in Miami soaking up the city before departure. Revisit South Beach, catch a last sunset at South Pointe Park, and ease back into city life after driving the Overseas Highway. If you’re returning an RV rental in Miami, this is the perfect time to refuel and reset before wrapping up your Florida Keys road trip itinerary.
Tips for Your Florida Keys Road Trip
Whether it’s your first RV trip or you’re a seasoned road-tripper, a little prep goes a long way. These tips will help you start your Florida Keys adventure with everything in place—minus the stress.
- Book campsites early. Florida State Parks fill up fast, especially in winter. You can reserve up to 11 months in advance on ReserveAmerica.
- Pack for the heat. Reef-safe sunscreen, UV-protective clothing, and breathable layers are must-haves. A portable fan for your RV doesn’t hurt either.
- Prep your RV gear. Make sure you’ve got leveling blocks, a water pressure regulator, electrical adapters, and bug spray. For a full list of what to bring, check out our RV camping packing list.
Once the wheels are rolling, the Keys unfold at their own pace. Here are a few road-savvy reminders to help you drive smoother, save money, and make the most of the journey.
- Expect tolls. The Florida Turnpike and Homestead Extension are tolled. A SunPass gets you the best rates. You can estimate your trip cost with the toll calculator.
- Fuel up when you can. Gas gets pricier the further you go into the Keys. Homestead and Key Largo usually offer the best prices.
- Mind the highway rhythm. US-1 (Overseas Highway) can get congested. Mornings are quieter—great for scenic stops with fewer crowds.
You’ve made it to the tropics—now it’s time to settle in. From fees to parking to doing right by the reef, these tips will help you camp comfortably and respectfully.
- Expect fees at state parks. Most charge $4–$8 per vehicle for day use. RV campsites range from $20–$42 per night plus a $7 utility fee. For details, see the fee schedule.
- Parking in Key West can be tricky for RVs. Look for outer lots—downtown options often have size restrictions and $4+/hr rates.
- Leave No Trace. Stick to trails, pack out your trash, and use reef-safe sunscreen to help protect local ecosystems and coral reefs.
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